Like Malfunkshun, Mother Love Bone would include elements of glam rock, but the stripped-down sound of Gossard and Ament's former band would also be included in the mix. Drummer Greg Gilmore and second guitarist Bruce Fairweather were also welcomed aboard, as Mother Love Bone quickly built up a loyal local following. Polygram signed the band in 1989, issuing the six-track EP Shine later in the year (on the band's own subsidiary label, Stardog), as Mother Love Bone opened up a nationwide tour for British glamsters Dogs d'Amour. By September of 1989, the quintet were hard at work on their full-length debut, but Wood had developed a drug addiction that became obvious to his bandmates, and spent the last months of the year in rehab. With expectations running high for MLB's debut album (to be titled Apple), Wood and the others started 1990 by playing a few shows around Seattle as they waited for the record's projected springtime release date. On March 16th, Wood was found comatose in his apartment by his girlfriend, having taken a lethal overdose of heroin. Wood was placed on life support, but the damage was already done, and he died three days later.

Mother Love Bone broke up shortly after Wood's death, while Apple was finally issued to glowing reviews later in the year. The Seattle rock scene was shaken to its core over the death of such a promising singer, as a longtime friend of Wood's, Chris Cornell, penned a few songs in tribute to his fallen comrade (and one-time roommate). With Gossard and Ament signed on to assist Cornell, the project was dubbed Temple of the Dog, taken from a lyric in the MLB song "Man of Golden Words." A full album was recorded, with Soundgarden drummer Matt Cameron and local guitarist Mike McCready, issued in mid-1991 to little fanfare. As many know, Gossard, Ament, and McCready went on to form the band Pearl Jam (with singer Eddie Vedder and a revolving door of drummers), finding breakthrough success in the summer of 1992. Shortly thereafter, Temple of the Dog enjoyed a second life and became a hit, while all of Mother Love Bone's recorded output for Polygram was compiled for a double-disc self-titled release the same year. MLB would remain in the spotlight for some time afterward -- their epic ballad "Chloe Dancer/Crown of Thorns" appeared on the soundtrack to the popular motion picture Singles, Alice in Chains wrote a song about Wood and other rockers who died from drugs ("Would?"), and a home video of the band was released as well -- Love Bone Earth Affair. In 1995, Gossard spotlighted Wood's early work with Malfunkshun by issuing the compilation Return to Olympus on his Loosegroove label.